Cyclic amine sulfonamides as linkers in the design and synthesis of novel human beta(3) adrenergic receptor agonists

Bioorg Med Chem Lett. 2003 Jul 7;13(13):2191-4. doi: 10.1016/s0960-894x(03)00387-1.

Abstract

Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human beta(3) adrenergic receptor (beta(3)-AR) agonists. The azetidine derivative 37, and piperidine derivatives 7, 8, and 13 were found to be potent beta(3)-AR agonists and have good selectivity against beta(1)- and beta(2)-AR.

MeSH terms

  • Adrenergic beta-3 Receptor Agonists*
  • Adrenergic beta-Agonists / chemical synthesis*
  • Adrenergic beta-Agonists / pharmacology*
  • Animals
  • Azetidines / chemical synthesis
  • Azetidines / pharmacology
  • CHO Cells
  • Cricetinae
  • Cyclization
  • Drug Design
  • Humans
  • Hydrogen Bonding
  • Molecular Conformation
  • Piperidines / chemical synthesis
  • Piperidines / pharmacology
  • Pyrrolidines / chemical synthesis
  • Pyrrolidines / pharmacology
  • Sulfonamides / chemistry*

Substances

  • Adrenergic beta-3 Receptor Agonists
  • Adrenergic beta-Agonists
  • Azetidines
  • Piperidines
  • Pyrrolidines
  • Sulfonamides