Abstract
Piperidine, pyrrolidine, and azetidine sulfonamides were examined as linkers in designing novel human beta(3) adrenergic receptor (beta(3)-AR) agonists. The azetidine derivative 37, and piperidine derivatives 7, 8, and 13 were found to be potent beta(3)-AR agonists and have good selectivity against beta(1)- and beta(2)-AR.
MeSH terms
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Adrenergic beta-3 Receptor Agonists*
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Adrenergic beta-Agonists / chemical synthesis*
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Adrenergic beta-Agonists / pharmacology*
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Animals
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Azetidines / chemical synthesis
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Azetidines / pharmacology
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CHO Cells
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Cricetinae
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Cyclization
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Drug Design
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Humans
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Hydrogen Bonding
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Molecular Conformation
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Piperidines / chemical synthesis
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Piperidines / pharmacology
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Pyrrolidines / chemical synthesis
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Pyrrolidines / pharmacology
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Sulfonamides / chemistry*
Substances
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Adrenergic beta-3 Receptor Agonists
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Adrenergic beta-Agonists
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Azetidines
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Piperidines
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Pyrrolidines
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Sulfonamides